18.12.2014, Impact of DHA on metabolic diseases from womb to tomb.

Mar Drugs. 2014 Dec 18;12(12):6190-212

Arnoldussen IA, Kiliaan AJ

Long chain polyunsaturated fatty acids (LC-PUFAs), are important for human health during life. We especially focus on the omega-3 LC-PUFA docosahexaenoic acid (DHA) which is abundantly present in fish. Adequate DHA levels are essential during neurodevelopment and important for brain functions throughout life but they are also important in cardiovascular diseases, obesity, and diabetes mellitus type 2.  All of these are risk factors for cognitive decline and dementia in later life. Intake of DHA also reduces incidence of both stroke and atherosclerosis, and diabetes prevalence. These findings are discussed in the light of different stages in the human life cycle: childhood, adolescence, adulthood and in later life. From this review, it can be concluded that DHA supplementation is able to inhibit obesity and cardiovascular disease. DHA could therefore be a dietary protector against these diseases during a person’s entire life.

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01.12.2014, Obesity and dementia: Adipokines interact with the brain.

Eur J Neuropsychopharmacology, 24(12):1982-99.

Arnoldussen IAC, Kiliaan AJ, Gustafson DR

If overweight and obesity are risk factors for dementia, then the next question is how?  Obesity is a pandemic and a serious global health concern. Obesity increases risk for multiple conditions that also increase dementia risk. Adipokines are hormones produced and released by adipose tissue that may influence brain health more than previously thought. In this review article, six adipose tissue hormones and their actions were discussed. It remains unclear as to the specific function of these hormones.

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15.10.2014, Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice

J Neurosci. 2014 Oct 15;34(42):13963-75.

Zerbi V, Wiesmann M, Emmerzaal TL, Jansen D, Van Beek M, Mutsaers MP, Beckmann CF, Heerschap A, Kiliaan AJ.

In this study we provide new evidence for a relation between the cholesterol transporter apoE and the integrity of connections between brain area, possibly due to impairment in the vasculature such as atherosclerosis and hypercholesterolemia. Our results show that neuroimaging techniques provide an excellent tool to assess brain function and to investigate early neuropathology and aging effects in translational research.

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01.09.2014, Adipokines: a link between obesity and dementia?

Lancet Neurol. 2014 Sep;13(9):913-923.

Kiliaan AJ, Arnoldussen IA, Gustafson DR.

Being overweight or obese, as measured using body mass index (BMI) or central adiposity (waist circumference), and changes in BMI over the life course have been associated with brain structure and function, as well as late-onset dementia and Alzheimer's disease (AD). This observation led us to question what it is about BMI that is associated with health of the brain and dementia risk. Hormones produced by adipose tissue may be an answer.

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01.09.2014, Vitamin D in relation to cognitive impairment, cerebrospinal fluid biomarkers, and brain volumes

The Journals of Gerontology, Series A, Biological sciences and medical sciences. 2014 Sept 01; 69(9):1132-1138

Hooshmand B, Lökk J, Solomon A, Mangialasche F, Miralbell J, Spulber G, Annerbo S, Andreasen N, Winblad B, Cedazo-Minguez A, Wahlund LO, Kivipelto M.

The study investigated associations between plasma vitamin D and cognitive impairment, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD), and brain tissue volumes in 79 memory clinic patients (29 with subjective cognitive impairment, 28 with mild cognitive impairment, 18 with AD). Results suggest that vitamin D may be associated with cognitive status, CSF Aβ42 levels, and brain tissue volumes (e.g. white matter, structures belonging to medial temporal lobe).

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